Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation‐contraction coupling

@article{Hidalgo1986PhosphorylationOP,
  title={Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation‐contraction coupling},
  author={Cecilia Hidalgo and Mar{\'i}a Ang{\'e}lica Carrasco and Karin Magendzo and Enrique Jaimovich},
  journal={FEBS Letters},
  year={1986},
  volume={202}
}
Intracellular localization of inositol-phospholipid-metabolizing enzymes in rabbit fast-twitch skeletal muscle. Can D-myo-inositol 1,4,5-trisphosphate play a role in excitation-contraction coupling?
TLDR
In rabbit fast-twitch skeletal muscle all necessary enzymes for production of D-myo-inositol 1,4,5-trisphosphate are associated with transverse tubules, and this correlates well with the observation that neither alpha 1-adrenergic nor muscarinic receptors have been found in fast- twitch rabbit skeletal muscle.
Inositol trisphosphate and excitation-contraction coupling in skeletal muscle
TLDR
It is clear that a role for inositol triphosphate in skeletal muscle function is highly likely; whether this molecule is the physiological messenger in excitation-contraction coupling remains to be established.
Calcium release modulated by inositol trisphosphate in ruptured fibers from frog skeletal muscle
TLDR
Results are consistent with a role for inositol 1,4,5-trisphosphate as a chemical modulator in excitation/contraction coupling in skeletal muscle.
Inositol 1,4,5-trisphosphate 3-kinase activity in frog skeletal muscle.
  • M. Carrasco, S. Figueroa
  • Biology, Computer Science
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 1995
Inositol trisphosphate, calcium and muscle contraction.
  • A. Somlyo, J. Walker, A. Somlyo
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1988
TLDR
Results suggest that activation of G protein(s) can release Ca2+ by, at least, two G-protein-regulated mechanisms: one mediated by Ins(1,4,5)P3 and the other Ins(2,3,3-independent).
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References

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Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle
TLDR
It is shown that Inositol 1,4,5-trisphosphate releases Ca2+ from isolated, purified sarcoplasmic reticulum fractions of rabbit fast-twitch skeletal muscle, the effect being more pronounced on a fraction of terminal cisternae that contains morphologically intact feet structures, and elicits isometric force development in chemically skinned muscle fibres.
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.
TLDR
It is proposed that InsP3 acts as a chemical second messenger between transverse (T)-tubular membrane depolarization and calcium release from the sarcoplasmic reticulum in skeletal muscle.
Enzymatic synthesis and hydrolysis of [32P]phosphatidylinositol phosphate.
Effects of tetracaine on displacement currents and contraction of frog skeletal muscle.
TLDR
The kinetics of mechanical activation of intact fibres were examined with a voltage‐clamp technique and it was shown that tetracaine blocks or greatly diminishes caffeine contractions, but that Cl‐induced contractions of normal amplitude are still possible.
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