Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells.

@article{Ku2000PhosphorylationOP,
  title={Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells.},
  author={H Ku and K. Eberhard Meier},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 15},
  pages={11333-40}
}
Intracellular signals can regulate cell adhesion via several mechanisms in a process referred to as "inside-out" signaling. In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion. In this study, clonal EL4 cell lines with varying abilities to activate ERKs in response to PMA were used to examine signaling events occurring downstream of ERK… CONTINUE READING
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