Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation

@inproceedings{Zheng2010PhosphorylationOP,
  title={Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation},
  author={Ya-li Zheng and B S Li and Parvathi Rudrabhatla and Varsha Shukla and Niranjana D. Amin and Dragan Maric and Sashi Kesavapany and Jyotshna Kanungo and Tej Kumar Pareek and Satoru Takahashi and Philip Grant and Ashok Kulkarni and Harish C. Pant},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Cyclin-dependent kinase 5 (Cdk5) plays a key role in the development of the mammalian nervous system; it phosphorylates a number of targeted proteins involved in neuronal migration during development to synaptic activity in the mature nervous system. Its role in the initial stages of neuronal commitment and differentiation of neural stem cells (NSCs… CONTINUE READING