Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification.

@article{Jono2000PhosphorylationOO,
  title={Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification.},
  author={Shuichi Jono and Carmen Mart{\'i}nez Peinado and Cecilia M. Giachelli},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 26},
  pages={
          20197-203
        }
}
Osteopontin (OPN) is a non-collagenous, glycosylated phosphoprotein associated with biomineralization in osseous tissues, as well as ectopic calcification. We previously reported that osteopontin was co-localized with calcified deposits in atherosclerotic lesions, and that osteopontin potently inhibits calcium deposition in a human smooth muscle cell (HSMC) culture model of vascular calcification. In this report, the role of phosphorylation in osteopontin's mineralization inhibitory function… CONTINUE READING

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Phosphorylated Osteopontin Function 20203 by gest on Sptem er 24

K. Singh, D. Deonarine, +5 authors B. B. Mukherjee
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