Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians.

@article{Stein2001PhosphorylationON,
  title={Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians.},
  author={Daniel S. Stein and Katrina H. Moore},
  journal={Pharmacotherapy},
  year={2001},
  volume={21 1},
  pages={
          11-34
        }
}
Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents for more than a decade. They undergo anabolic phosphorylation by intracellular kinases to form triphosphates, which inhibit human immunodeficiency virus replication by competitively inhibiting viral reverse transcriptase. Numerous methods are used to elucidate the intracellular metabolic pathways of these agents. Intracellular and extracellular factors affect… CONTINUE READING
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