Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation.

@article{Hirota1999PhosphorylationON,
  title={Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation.},
  author={Masako Hirota and Sachie Satoh and Shinichi Asabe and Michinori Kohara and Kyoko Tsukiyama-Kohara and Nobuyuki Kato and Makoto Hijikata and Kunitada Shimotohno},
  journal={Virology},
  year={1999},
  volume={257 1},
  pages={130-7}
}
We previously showed that two proteins with molecular weights of 56 and 58 kDa are produced from nonstructural protein 5A (NS5A) derived from hepatitis C virus (HCV)-1b genotype. The 56-kDa protein is phosphorylated at serine residues in NS5A, including those located in the C-terminal region of NS5A, while the 58-kDa protein, the hyperphosphorylated form of the 56-kDa protein, is phosphorylated at serine residues in the central region. This hyperphosphorylation is dependent on the presence of… CONTINUE READING

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References

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Showing 1-10 of 19 references

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the NS5Aassociated kinase

K. eed, J. Xu, C. M. Rice
J. Virol • 1997

The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation

S. sabe, Y. Tanji, +3 authors K. Shimotohno
J. Virol • 1997

Hepatitis C virus polyprotein processing: Kinetics and mutagenetic analysis of serine protease-dependent cleavage

Y. anji, M. Hijikata, Y. Hirowatari, K. Shimotohno
J. Virol • 1994

Identification of the domain required for trans-cleavage activity of hepatitis C viral serine protease

Y. anji, M. Hijikata, Y. Hirowatari, K. Shimotohno
Gene 145, • 1994

Characterization of the hepatitis C virus-encoded serine protease: Determination of protease-dependent polyprotein cleavage sites

A. rakoui, D. W. McCount, C. Wychowski, S. M. Feinstone, C. M. Rice
J. Virol • 1993

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