Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs.

  title={Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs.},
  author={Brad M Binder and T M O'Connor and M. Deric Bownds and Vadim Y Arshavsky},
  journal={The Journal of biological chemistry},
  volume={271 33},
The photoresponse in retinal photoreceptors begins when a molecule of rhodopsin is excited by a photon of light. Photoexcited rhodopsin activates an enzymatic cascade including the G-protein transducin and cyclic GMP phosphodiesterase. As a result, cytoplasmic cyclic GMP concentration is decreased and the photoresponse is initiated. This process is terminated when rhodopsin is phosphorylated by rhodopsin kinase and subsequently blocked by a protein called arrestin. It has been noted by several… CONTINUE READING


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