Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry.

@article{Liu2010PhosphorylationOM,
  title={Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry.},
  author={Jie Liu and Xiao Ning Wang and Fei Xiong Cheng and Yih-Cherng Liou and Lih-Wen Deng},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 27},
  pages={20904-14}
}
The human mixed lineage leukemia-5 (MLL5) gene is frequently deleted in myeloid malignancies. Emerging evidence suggests that MLL5 has important functions in adult hematopoiesis and the chromatin regulatory network, and it participates in regulating the cell cycle machinery. Here, we demonstrate that MLL5 is tightly regulated through phosphorylation on its… CONTINUE READING

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