Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

@article{Gong2000PhosphorylationOM,
  title={Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.},
  author={Congyang Gong and Theodore I. Lidsky and Jerzy Wegiel and Lenore D. Zuck and Inge Grundke-Iqbal and Khalid Iqbal},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 8},
  pages={
          5535-44
        }
}
Hyperphosphorylated tau, which is the major protein of the neurofibrillary tangles in Alzheimer's disease brain, is most probably the result of an imbalance of tau kinase and phosphatase activities in the affected neurons. By using metabolically competent rat brain slices as a model, we found that selective inhibition of protein phosphatase 2A by okadaic acid induced an Alzheimer-like hyperphosphorylation and accumulation of tau. The hyperphosphorylated tau had a reduced ability to bind to… CONTINUE READING

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