Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

@inproceedings{Grieve2017PhosphorylationOI,
  title={Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling},
  author={Adam Graham Grieve and Hongmei Xu and Ulrike K{\"u}nzel and Paul J Bambrough and Boris Sieber and Matthew Freeman},
  booktitle={eLife},
  year={2017}
}
Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor receptor. iRhoms, catalytically inactive members of the rhomboid-like superfamily, have been shown to control the ER-to-Golgi transport and maturation of TACE. Here, we reveal that iRhom2 remains associated… CONTINUE READING
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