Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions

@inproceedings{Lee2018PhosphorylationOH,
  title={Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions},
  author={Kyung ho Lee and Jeong-Ah Hwang and Sun-Ok Kim and Jung Hee Kim and Sang Chul Shin and Eunice Eunkyeong Kim and Kyung S Lee and Kunsoo Rhee and Byeong Hwa Jeon and Jeong Kyu Bang and Hyunjoo Cha-Molstad and Nak-Kyun Soung and Jae-Hyuk Jang and Sung-Kyun Ko and Hee Gu Lee and Jong Seog Ahn and Yong Tae Kwon and Bo Yeon Kim},
  booktitle={The Journal of biological chemistry},
  year={2018}
}
Elevated expression of human enhancer filamentation 1 (HEF1; also known as NEDD9 or Cas-L) is an essential stimulus for the metastatic process of various solid tumors. This process requires HEF1 localization to focal adhesions (FAs). Although the association of HEF1 with FAs is considered to play a role in cancer cell migration, the mechanism targeting HEF1… CONTINUE READING