Phosphorylation of histone H3 at Thr3 is part of a combinatorial pattern that marks and configures mitotic chromatin.

@article{Markaki2009PhosphorylationOH,
  title={Phosphorylation of histone H3 at Thr3 is part of a combinatorial pattern that marks and configures mitotic chromatin.},
  author={Yolanda Markaki and Anastasia Christogianni and A. S. Politou and Spyros D. Georgatos},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 16},
  pages={2809-19}
}
We have previously shown that histone H3 is transiently phosphorylated at Thr3 during mitosis. Extending these studies, we now report that phosphorylated Thr3 is always in cis to trimethylated Lys4 and dimethylated Arg8, forming a new type of combinatorial modification, which we have termed PMM. PMM-marked chromatin emerges at multiple, peripheral sites of the prophase nucleus, then forms distinct clusters at the centric regions of metaphase chromosomes, and finally spreads (as it wanes) to the… CONTINUE READING

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