Phosphorylation of galectin-3 contributes to malignant transformation of human epithelial cells via modulation of unique sets of genes.

@article{Mazurek2005PhosphorylationOG,
  title={Phosphorylation of galectin-3 contributes to malignant transformation of human epithelial cells via modulation of unique sets of genes.},
  author={Nachman Mazurek and Yun Jie Sun and Janet E. Price and Latha Ramdas and Wendy D. Schober and Pratima Nangia-Makker and James C. Byrd and Avraham Raz and Robert S. Bresalier},
  journal={Cancer research},
  year={2005},
  volume={65 23},
  pages={10767-75}
}
Galectin-3 is a multifunctional beta-galactoside-binding protein implicated in apoptosis, malignant transformation, and tumor progression. The mechanisms by which galectin-3 contributes to malignant progression are not fully understood. In this study, we found that the introduction of wild-type galectin-3 into nontumorigenic, galectin-3-null BT549 human breast epithelial cells conferred tumorigenicity and metastatic potential in nude mice, and that galectin-3 expressed by the cells was… CONTINUE READING

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