Phosphorylation of focal adhesion kinase tyrosine 397 critically mediates gastrin-releasing peptide's morphogenic properties.

@article{Glover2004PhosphorylationOF,
  title={Phosphorylation of focal adhesion kinase tyrosine 397 critically mediates gastrin-releasing peptide's morphogenic properties.},
  author={Sarah C Glover and Melissa Delaney and C. Dematt{\`e} and Lori Kornberg and Melissa A. Frasco and Roger Tran-Son-Tay and Richard V. Benya},
  journal={Journal of cellular physiology},
  year={2004},
  volume={199 1},
  pages={77-88}
}
We have proposed that gastrin-releasing peptide (GRP) and its receptor (GRP-R) are morphogens that when aberrantly re-expressed in colon cancer promote tumor cell differentiation and retard metastasis. Because circumstantial evidence suggested that these properties were mediated via focal adhesion kinase (FAK), the purpose of this study was to elucidate the role of GRP-induced activation of this enzyme on properties fundamental to metastasis including cell attachment, motility, and… CONTINUE READING
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