Phosphorylation of farnesol by a cell-free system from Botryococcus braunii.

@article{Inoue1994PhosphorylationOF,
  title={Phosphorylation of farnesol by a cell-free system from Botryococcus braunii.},
  author={Hitoshi Inoue and Tatsumi Korenaga and Hiroshi Sagami and Takako Koyama and Kyozo Ogura},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={200 2},
  pages={
          1036-41
        }
}
Farnesol was incorporated into squalene as well as botryococcenes when the alcohol was fed to the culture of Botryococcus braunii B race strain. In in vitro experiments with a 10,000 x g supernatant of cell homogenate, squalene was synthesized from farnesyl diphosphate in the presence of NADPH or NADH, but botryococcenes were not synthesized under the same conditions. A 100,000 x g pelet fraction was able to phosphorylate farnesol to give its mono- and diphosphate esters in a CTP dependent… 
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Botryococcus braunii: A Renewable Source of Hydrocarbons and Other Chemicals
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This review details the various facets of biotechnology of B. braunii, including its microbiology and physiology; production of hydrocarbons and other compounds by the alga; methods of culture; downstream recovery and processing of algal hydrocarols; and cloning of the algal genes into other microorganisms.
Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactions.
  • L. Thai, J. Rush, C. J. Waechter
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
These results document the presence of at least two CTP-mediated kinases that provide a mechanism for the utilization of F-OH and GG-OH for the biosynthesis of isoprenoid lipids and protein isopranylation.
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