Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.

@article{Zhan2002PhosphorylationOE,
  title={Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.},
  author={Ke Zhan and Krishna M. Vattem and Bettina N. Bauer and Thomas E. Dever and Jane-Jane Chen and Ronald C Wek},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 20},
  pages={7134-46}
}
Protein synthesis is regulated by the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in response to different environmental stresses. One member of the eIF2alpha kinase family, heme-regulated inhibitor kinase (HRI), is activated under heme-deficient conditions and blocks protein synthesis, principally globin, in mammalian erythroid cells. We identified two HRI-related kinases from Schizosaccharomyces pombe which have full-length homology with mammalian HRI… CONTINUE READING
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