Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress.

  title={Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress.},
  author={Marshall A. Corson and N L James and Shadi Latta and Robert M. Nerem and Bradford C. Berk and David G Harrison},
  journal={Circulation research},
  volume={79 5},
Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine aortic endothelial cells exposed to shear stress in a laminar flow chamber or treated with Ca2+ ionophores in static culture. The kinetics of cumulative NO production varied… CONTINUE READING


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