Phosphorylation of eEF1A1 at Ser300 by TβR-I Results in Inhibition of mRNA Translation

  title={Phosphorylation of eEF1A1 at Ser300 by TβR-I Results in Inhibition of mRNA Translation},
  author={Kah Wai Lin and Ihor Yakymovych and Min Jia and Mariya Yakymovych and Serhiy Souchelnytskyi},
  journal={Current Biology},
BACKGROUND Transforming growth factor β (TGF-β) is a potent inhibitor of cell proliferation that regulates cell functions by activating specific serine/threonine kinase receptors on the cell surface. Type I TGF-β receptor (TβR-I) is essential for TGF-β signaling, and substrates of TβR-I provide insights into molecular mechanisms of TGF-β signaling. RESULTS Here we identify eukaryotic elongation factor 1A1 (eEF1A1) as a novel substrate of TβR-I. We show that TβR-I phosphorylates eEF1A1 at… CONTINUE READING


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