Phosphorylation of cardiac protein kinase B is regulated by palmitate.

@article{Soltys2002PhosphorylationOC,
  title={Phosphorylation of cardiac protein kinase B is regulated by palmitate.},
  author={Carrie-Lynn M. Soltys and L. Buchholz and M. Gandhi and A. Clanachan and K. Walsh and J. Dyck},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 3},
  pages={
          H1056-64
        }
}
  • Carrie-Lynn M. Soltys, L. Buchholz, +3 authors J. Dyck
  • Published 2002
  • Medicine, Biology
  • American journal of physiology. Heart and circulatory physiology
  • In this study isolated perfused working rat hearts were used to investigate the role of palmitate-regulated protein kinase B (PKB) phosphorylation on glucose metabolism. Rat hearts were perfused aerobically in working mode with 11 mM glucose and either 100 microU/ml insulin or 100 microU/ml insulin and 1.2 mM palmitate. PKB activity and phosphorylation state were reduced in the presence of 1.2 mM palmitate, which correlates with a decrease in glycolysis (47%), glucose oxidation (84%), and… CONTINUE READING

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