Phosphorylation of cardiac protein kinase B is regulated by palmitate.

  title={Phosphorylation of cardiac protein kinase B is regulated by palmitate.},
  author={Carrie-Lynn M. Soltys and Lori Buchholz and Manoj Gandhi and Alexander A S C Clanachan and Kenneth Walsh and Jason R. B. Dyck},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={283 3},
In this study isolated perfused working rat hearts were used to investigate the role of palmitate-regulated protein kinase B (PKB) phosphorylation on glucose metabolism. Rat hearts were perfused aerobically in working mode with 11 mM glucose and either 100 microU/ml insulin or 100 microU/ml insulin and 1.2 mM palmitate. PKB activity and phosphorylation state were reduced in the presence of 1.2 mM palmitate, which correlates with a decrease in glycolysis (47%), glucose oxidation (84%), and… CONTINUE READING
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Phosphorylation and activation of heart 6-phosphofructo-2-ki H1063 REGULATION OF PKB BY PALMITATE AJP-Heart

  • J Deprez, D Vertommen, DR Alessi, L Hue, MH. Rider
  • Circ Physiol
  • 2002
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