Phosphorylation of caldesmon during smooth muscle contraction and cell migration or proliferation.

@article{Kordowska2006PhosphorylationOC,
  title={Phosphorylation of caldesmon during smooth muscle contraction and cell migration or proliferation.},
  author={Jolanta Kordowska and Renjian Huang and C L Albert Wang},
  journal={Journal of biomedical science},
  year={2006},
  volume={13 2},
  pages={159-72}
}
The actin-binding protein caldesmon (CaD) exists both in smooth muscle (the heavy isoform, h-CaD) and non-muscle cells (the light isoform, l-CaD). In smooth muscles h-CaD binds to myosin and actin simultaneously and modulates the actomyosin interaction. In non-muscle cells l-CaD binds to actin and stabilizes the actin stress fibers; it may also mediate the interaction between actin and non-muscle myosins. Both h- and l-CaD are phosphorylated in vivo upon stimulation. The major phosphorylation… CONTINUE READING

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