Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase.

  title={Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase.},
  author={James E. Thomas and Philippe Soriano and Joan S. Brugge},
  volume={254 5031},
The protein tyrosine kinase activity of the cellular Src protein is negatively regulated by phosphorylation at tyrosine residue 527 (Tyr527). It has not been established whether this regulatory modification of Src is mediated by autophosphorylation or by another cellular protein kinase. The phosphorylation of a modified form of c-Src that lacks kinase activity was examined in mouse cells that do not express endogenous Src (because of the targeted disruption of both src alleles). Phosphorylation… CONTINUE READING

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