Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.

  title={Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.},
  author={Dexing Fang and David J. Hawke and Yanhua Zheng and Yan Xia and Jill Meisenhelder and Heinz Nika and Gordon B. Mills and Ryuji Kobayashi and Tony Hunter and Zhimin Lu},
  journal={The Journal of biological chemistry},
  volume={282 15},
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling, phosphorylates beta-catenin at Ser552 in vitro and in vivo. AKT-mediated phosphorylation of beta-catenin causes its disassociation from cell… CONTINUE READING
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