Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization.

Abstract

G-protein receptor kinase and beta-arrestin mediated desensitization of the rat kappa-opioid receptor (KOR) was previously shown using Xenopus oocyte expression to require serine 369 within the C terminus of KOR. To define the effects of phosphorylation of this residue in desensitization and internalization processes in mammalian expression systems, wild… (More)

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Cite this paper

@article{McLaughlin2003PhosphorylationOA, title={Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization.}, author={Jay P. McLaughlin and Mei Xu and Ken Mackie and Charles C. Chavkin}, journal={The Journal of biological chemistry}, year={2003}, volume={278 36}, pages={34631-40} }