Phosphorylation of a 72-kDa nucleoprotein (NP-72) in HL-60 cells is mediated by the double-stranded DNA-dependent protein kinase (DNA-PK).


Nuclear extracts prepared from human leukemic cells grown in the presence of cell differentiation-inducing agents showed a significant increase in the phosphorylation of a nuclear protein referred to as NP-72. The NP-72 phosphorylation was greatly increased by the addition of purified HeLa DNA-PK and was reduced by the inclusion of a DNA-PK-specific… (More)


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