Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

@inproceedings{Orsenigo2012PhosphorylationOV,
  title={Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo},
  author={Francesco Orsenigo and Costanza Giampietro and Aldo Ferrari and Monica Corada and Ariane Galaup and Sara Sigismund and Giuseppe Ristagno and Luigi Maddaluno and Gou Young Koh and Davide Franco and Vartan Kurtcuoglu and Dimos Poulikakos and Peter Baluk and Dana Marie Mcdonald and Maria Grazia Lampugnani and Elisabetta Dejana},
  booktitle={Nature communications},
  year={2012}
}
Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their permeability but whether organization and strength of their adherens junctions vary has not been demonstrated in vivo. Here we report that vascular endothelial cadherin, an endothelial specific adhesion protein located at adherens junctions, is phosphorylated in Y658 and Y685 in vivo in veins but not in arteries under resting conditions. This difference is due to shear stress-induced junctional Src… CONTINUE READING
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