Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning.

  title={Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning.},
  author={Shinya Takemasu and K. Nigorikawa and M. Yamada and Go Tsurumi and S. Kofuji and Shunsuke Takasuga and K. Hazeki},
  journal={Journal of biochemistry},
  • Shinya Takemasu, K. Nigorikawa, +4 authors K. Hazeki
  • Published 2019
  • Chemistry, Medicine
  • Journal of biochemistry
  • TMEM55B is first identified as phosphatidylinositol-4,5-P24-phosphatases (PtdIns-4,5-P24-phosphatases) that catalyse dephosphorylation of PtdIns-4,5-P2 to PtdIns-5-P. We demonstrate for the first time that TMEM55B is phosphorylated by Erk/MAPK and that this mechanism participates in regulation of lysosomal clustering. Exposure of RAW264.7 macrophages to various stimuli induces phosphorylation of TMEM55B on Ser76 and Ser169, sites corresponding to consensus sequences (PX(S/T)P) for… CONTINUE READING
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