Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.

@article{Shimada2009PhosphorylationOS,
  title={Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.},
  author={Atsushi Shimada and Kohei Dohke and Mahito Sadaie and Kaori Shinmyozu and Jun-ichi Takefu-shi Nakayama and Takeshi Narita Urano and Yota Murakami},
  journal={Genes & development},
  year={2009},
  volume={23 1},
  pages={
          18-23
        }
}
Heterochromatin protein 1 (HP1) recruits various effectors to heterochromatin for multiple functions, but its regulation is unclear. In fission yeast, a HP1 homolog Swi6 recruits SHREC, Epe1, and cohesin, which are involved in transcriptional gene silencing (TGS), transcriptional activation, and sister chromatid cohesion, respectively. We found that casein kinase II (CK2) phosphorylated Swi6. Loss of CK2-dependent Swi6 phosphorylation alleviated heterochromatic TGS without affecting… CONTINUE READING

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