Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.


The ends of coiled-coil tropomyosin molecules are joined together by nine to ten residue-long head-to-tail "overlapping domains". These short four-chained interconnections ensure formation of continuous tropomyosin cables that wrap around actin filaments. Molecular Dynamics simulations indicate that the curvature and bending flexibility at the overlap is 10… (More)
DOI: 10.1016/