Phosphorylation of Ser-3 of cofilin regulates its essential function on actin.

  title={Phosphorylation of Ser-3 of cofilin regulates its essential function on actin.},
  author={Kenji Moriyama and Kazuko Iida and Ichiro Yahara},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={1 1},
BACKGROUND Cofilin is a low-molecular weight actin-modulating protein, and is structurally and functionally conserved in eucaryotes from yeast to mammals. The functions of cofilin appear to be regulated by phosphorylation and dephosphorylation. RESULTS A proteolytic study of phosphorylated porcine cofilin and expression of a mutated cofilin in cultured cells revealed that Ser-3 is the unique phosphorylation site. Phosphorylated cofilin was found not to bind to either F- or G-actin while… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 149 extracted citations

Similar Papers

Loading similar papers…