Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.

  title={Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.},
  author={Ivan Matic and Boris Ma{\vc}ek and Maximiliane Hilger and Tobias C. Walther and Matthias Mann},
  journal={Journal of proteome research},
  volume={7 9},
Protein dynamics is regulated by an elaborate interplay between different post-translational modifications. Ubiquitin and ubiquitin-like proteins (Ubls) are small proteins that are covalently conjugated to target proteins with important functional consequences. One such modifier is SUMO, which mainly modifies nuclear proteins. SUMO contains a unique N-terminal arm not present in ubiquitin and other Ubls, which functions in the formation of SUMO polymers. Here, we unambiguously show that serine… CONTINUE READING


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