Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

  title={Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation},
  author={Kotaro Suzuki and Inder M Verma},
Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (FcepsilonRI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms of IgE-dependent exocytosis remain unknown. We show here that IkappaB kinase (IKK) 2 in mast cells plays critical roles in IgE-mediated anaphylaxis in vivo, and IgE-mediated degranulation in vitro, in an NF-kB-independent manner. Upon FcvarepsilonRI stimulation, IKK2 phosphorylates… CONTINUE READING
64 Citations
41 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 64 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…