Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.

@article{Xie2010PhosphorylationOR,
  title={Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.},
  author={Zhihui Xie and Zhao Yang and Kirk M. Druey},
  journal={Journal of molecular cell biology},
  year={2010},
  volume={2 6},
  pages={357-65}
}
Regulators of G-protein signaling (RGS) proteins are scaffolds that control diverse signaling pathways by modulating signalosome formation and by accelerating the GTPase activity of heterotrimeric G proteins. Although expression of many RGS proteins is relatively low in quiescent cells, transcriptional and post-translational responses to environmental cues regulate both their abundance and activity. We found previously that RGS13, one of the smallest RGS proteins in the family, inhibited cyclic… CONTINUE READING

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