Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.

@article{Rondinone2000PhosphorylationOP,
  title={Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.},
  author={Christina M Rondinone and Eug{\'e}nia Carvalho and Tiit Rahn and Vincent C. Manganiello and Eva Degerman and U. P. G. Smith},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 14},
  pages={10093-8}
}
Phosphatidylinositol 3-kinase mediates several actions of insulin including its antilipolytic effect. This effect is elicited by the insulin-stimulated serine phosphorylation and activation of cGMP-inhibited phosphodiesterase (PDE3B). In human adipocytes, we found that insulin differentially stimulated phosphatidylinositol 3-kinase activity; the lipid kinase activity was associated with IRS-1, whereas the serine kinase activity was associated with the insulin receptor and phosphorylated a… CONTINUE READING

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