Phosphorylation of Neuroglycan C, a Brain-specific Transmembrane Chondroitin Sulfate Proteoglycan, and Its Localization in the Lipid Rafts*

  title={Phosphorylation of Neuroglycan C, a Brain-specific Transmembrane Chondroitin Sulfate Proteoglycan, and Its Localization in the Lipid Rafts*},
  author={Shinobu Yamauchi and Yoshihito Tokita and Sachiko Aono and Fumiko Matsui and Takuya Shuo and Hidenori Ito and Kanefusa Kato and Kohji Kasahara and Atsuhiko Oohira},
  journal={The Journal of Biological Chemistry},
  pages={20583 - 20590}
Neuroglycan C (NGC) is a brain-specific transmembrane chondroitin sulfate proteoglycan. In the present study, we examined whether NGC could be phosphorylated in neural cells. On metabolic labeling of cultured cerebral cortical cells from the rat fetus with 32Pi, serine residues in NGC were radiolabeled. Some NGC became detectable in the raft fraction from the rat cerebrum, a signaling microdomain of the plasma membrane, with cerebral development. NGC from the non-raft fraction, not the raft… 

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