Phosphorylation of NUMA occurs during nuclear breakdown and not mitotic spindle assembly.

@article{Sparks1995PhosphorylationON,
  title={Phosphorylation of NUMA occurs during nuclear breakdown and not mitotic spindle assembly.},
  author={Cynthia A. Sparks and Edward G. Fey and Charles A. Vidair and Stephen John Doxsey},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 11)},
  pages={
          3389-96
        }
}
NuMA, the nuclear mitotic apparatus protein, is a component of the nuclear matrix at interphase that redistributes to the spindle poles at mitosis. While the function of NuMA is not known, it has been implicated in spindle organization during mitosis and nuclear reformation. Phosphorylation is thought to play a regulatory role in NuMA function. In this study, NuMA phosphorylation was examined through the cell cycle using highly synchronized cells. In intact cells labeled with 32P-orthophosphate… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Phosphorylation regulates the assembly of NuMA in a mammalian mitotic extract.

  • Journal of cell science
  • 1997
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis

D. A. Compton, C. Luo
  • J. Cell Sci. 108,
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Primary structure

D. A. Compton, J. Szilak, D. W. Cleveland
  • 1992
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL