Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation.

@article{He2003PhosphorylationON,
  title={Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation.},
  author={Bin He and Georg F Weber},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 10},
  pages={2174-85}
}
The transcription factor NF-kappaB is activated in cellular stress responses. This requires rapid regulation of its function, which is accomplished, in part, by various modes of phosphorylation. Even though diverse DNA binding subunits of NF-kappaB proteins may transactivate from distinct recognition sequences, the differential regulation of transcription from the large number of NF-kappaB responsive sites in various gene promoters and enhancers has been incompletely understood. The cyclic GMP… CONTINUE READING

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