Phosphorylation of Mitogen- and Stress-Activated Protein Kinase-1 in Astrocytic Inflammation: A Possible Role in Inhibiting Production of Inflammatory Cytokines

@article{Gong2013PhosphorylationOM,
  title={Phosphorylation of Mitogen- and Stress-Activated Protein Kinase-1 in Astrocytic Inflammation: A Possible Role in Inhibiting Production of Inflammatory Cytokines},
  author={Peipei Gong and Xide Xu and Jinlong Shi and Lan-chun Ni and Qingfeng Huang and Liang Xia and Dekang Nie and Xiao-jian Lu and Jian Chen and Wei Shi},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Purpose It is generally accepted that inflammation has a role in the progression of many central nervous system (CNS) diseases, although the mechanisms through which this occurs remain unclear. Among mitogen-activated protein kinase (MAPK) targets, mitogen- and stress-activated protein kinase (MSK1) has been thought to be involved in the pathology of inflammatory gene expression. In this study, the roles of MSK1 activation in neuroinflammation were investigated. Methods The bacterial… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide
TLDR
Results demonstrate that H89 inhibits the activation of CREB and the CREB-mediated MKP-1 induction by LPS, which may result from its inhibition of PKA and MSK. Expand
The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6
TLDR
The molecular mechanism of MPTP-induced neuroinflammation and its modulation by melatonin in astrocytoma cells (C6) was elucidated and treated with deprenyl elucidated. Expand
Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia.
TLDR
The results suggest that astaxanthin regulates IL-6 production through a p-ERK1/2-MSK-1- and p-NF-κB p65-dependent pathway in activated microglial cells. Expand
Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins
TLDR
It is shown here that neurotrophin-induced CREB phosphorylation in CNS neurons depends exclusively on the extracellular signal-regulated kinase 1/2-activated kinase mitogen- and stress-activated protein kinases 1 (MSK1). Expand
Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation1
TLDR
It is found that p38α deficiency causes a significant inhibition in the production of LPS-induced TNF-α, IL-12, and IL-18, but it has little or no effect on IL-6 or IFN-β production. Expand
Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
TLDR
It is suggested that MSK1 may mediate the growth‐factor and stress‐induced activation of CREB, and exclude a role for MAPK AP‐K1 and MAPKAP‐K2/3 in this process. Expand
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
TLDR
The results establish MSK1 and MSK2 as key components of negative feedback mechanisms needed to limit Toll-like receptor–driven inflammation. Expand
Resveratrol differentially modulates inflammatory responses of microglia and astrocytes
TLDR
The results suggest that murine microglia and astrocytes produce proinflammatory cytokines and NO in response to LPS in a similar pattern with some differences in signaling molecules involved, and suggest that resveratrol exerts anti-inflammatory effects in microglIA and astROcytes by inhibiting different pro inflammatory cytokine and key signaling molecules. Expand
The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system
TLDR
Western blot data demonstrate a distinct regulation of the activation of ERK1/2 and p38MAPK in the three visual areas analyzed which occurs in temporal correlation with critical events for visual system maturation. Expand
Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation
TLDR
It is suggested that astrocytes could cooperate with microglia to prevent excessive inflammatory responses in the brain by regulating microglial expression of HO-1 and production of ROS. Expand
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