Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.

Abstract

Activating mutations in the kinase domain of epidermal growth factor receptor (EGFR) leads to the constitutively active kinase, improves the EGFR stability and promotes malignant transformation in lung adenocarcinoma. Despite the clinical significance, the mechanism by which the increased kinase activity stabilizes the receptor is not completely understood… (More)
DOI: 10.1016/j.cellsig.2017.11.006

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Cite this paper

@article{Boopathy2017PhosphorylationOM, title={Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.}, author={Gandhi T. K. Boopathy and Julia Lim Sze Lynn and Sheena Wee and Jayantha Gunaratne and Wanjin Hong}, journal={Cellular signalling}, year={2017}, volume={43}, pages={21-31} }