Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.

Abstract

Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are required for this proteolysis. In addition… (More)

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Cite this paper

@article{Kitamura2001PhosphorylationOM, title={Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.}, author={Ken Kitamura and Shigehiro Katayama and Susheela Dhut and Masaaki Sato and Yuki Watanabe and M. Yamamoto and Tosifusa Toda}, journal={Developmental cell}, year={2001}, volume={1 3}, pages={389-99} }