Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.

Abstract

Although tricyclic antidepressants rapidly activate monoaminergic neurotransmission, these drugs must be administered chronically to alleviate symptoms of depression. This observation suggests that molecular mechanisms downstream of monoamine receptor activation, which include the induction of gene transcription, underlie chronic antidepressant-induced… (More)
DOI: 10.1523/JNEUROSCI.2156-12.2012

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Cite this paper

@article{Hutchinson2012PhosphorylationOM, title={Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.}, author={Ashley N. Hutchinson and Jay V Deng and Sonia Cohen and Anne E West}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2012}, volume={32 41}, pages={14355-63} }