Phosphorylation of MdmX by CDK2/Cdc2p34 is required for nuclear export of Mdm2


Mdm2 and MdmX function as cellular regulators of the p53 tumor suppressor protein. Intriguingly, the activities of these proteins are interdependent; MdmX stabilizes Mdm2, enabling its activities towards p53, but it also requires Mdm2 for its nuclear localization. Here we demonstrate that via its phosphorylation by CDK2/Cdc2p34, MdmX regulates nuclear… (More)
DOI: 10.1038/sj.onc.1208768


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