Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy.

@article{Wilkinson2015PhosphorylationOL,
  title={Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy.},
  author={Deepti S Wilkinson and Jinel S Jariwala and Ericka L. Anderson and Koyel Mitra and Jill Meisenhelder and Jessica Chang and Trey Ideker and Tony Hunter and Victor Nizet and Andrew G Dillin and Malene Hansen},
  journal={Molecular cell},
  year={2015},
  volume={57 1},
  pages={55-68}
}
The protein LC3 is indispensible for the cellular recycling process of autophagy and plays critical roles during cargo recruitment, autophagosome biogenesis, and completion. Here, we report that LC3 is phosphorylated at threonine 50 (Thr(50)) by the mammalian Sterile-20 kinases STK3 and STK4. Loss of phosphorylation at this site blocks autophagy by impairing fusion of autophagosomes with lysosomes, and compromises the ability of cells to clear intracellular bacteria, an established cargo for… CONTINUE READING
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Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

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