Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes.

@article{Danielsson2006PhosphorylationOI,
  title={Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes.},
  author={Anna Danielsson and Fredrik H Nystrom and Peter Str{\aa}lfors},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 4},
  pages={1183-7}
}
Feedback control in insulin signaling involves serine phosphorylation of insulin receptor substrate-1 (IRS1). By analyzing the insulin-induced phosphorylation of IRS1 at serine 307, serine 312, and tyrosine in the same primary human adipocytes, we now report that negative feedback phosphorylation of serine 312 (corresponding to murine serine 307) required relatively high concentrations of insulin (EC(50)=3 nM) for a long time (t(1/2) ca. 30 min) and reduced the steady-state tyrosine… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Burn injury-induced IRS-1 degradation in mouse skeletal muscle.

International journal of burns and trauma • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…