Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling.

@article{Sun2009PhosphorylationOI,
  title={Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling.},
  author={X. J. Sun and F. Liu},
  journal={Vitamins and hormones},
  year={2009},
  volume={80},
  pages={
          351-87
        }
}
  • X. J. Sun, F. Liu
  • Published 2009
  • Biology, Medicine
  • Vitamins and hormones
  • Growing evidence reveals that insulin signal pathway is not static, but is rather a dynamic, flexible, and fed in by negative (Yin) and positive (Yang) regulation in response to environmental changes. Normal insulin response reflects the balance between Yin and Yang regulation acting upon insulin signaling pathway. Conceivably, imbalance between the Yin and Yang results in abnormal insulin sensitivity such as insulin resistance. IRS-proteins are insulin receptor substrates that mediate insulin… CONTINUE READING
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    References

    SHOWING 1-10 OF 251 REFERENCES
    Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
    • 748
    IRS proteins and the common path to diabetes.
    • M. White
    • Biology, Medicine
    • American journal of physiology. Endocrinology and metabolism
    • 2002
    • 832
    • PDF
    Role of Rho-kinase in regulation of insulin action and glucose homeostasis.
    • 137
    • Highly Influential
    Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.
    • 35
    • PDF
    Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
    • 832
    • PDF
    Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.
    • 152
    • PDF
    Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210
    • 626
    • Highly Influential
    • PDF
    Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302*
    • 217
    • PDF
    In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents*
    • 102
    • PDF
    Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
    • 334
    • Highly Influential