Phosphorylation of IRS proteins, insulin action, and insulin resistance.

@article{BouraHalfon2009PhosphorylationOI,
  title={Phosphorylation of IRS proteins, insulin action, and insulin resistance.},
  author={Sigalit Boura-Halfon and Yehiel Zick},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 4},
  pages={
          E581-91
        }
}
Insulin signaling at target tissues is essential for growth and development and for normal homeostasis of glucose, fat, and protein metabolism. Control over this process is therefore tightly regulated. It can be achieved by a negative feedback control mechanism whereby downstream components inhibit upstream elements along the insulin-signaling pathway (autoregulation) or by signals from apparently unrelated pathways that inhibit insulin signaling thus leading to insulin resistance… CONTINUE READING

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