Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore.

@article{Yang2008PhosphorylationOH,
  title={Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore.},
  author={Yong Yang and Fang Wu and Tarsha L Ward and Feng Yan and Quan Cai Wu and Zhaoyang Wang and Tanisha Z. McGlothen and Wei Peng and Tianpa You and Mingkuan Sun and Taixing Cui and Renming Hu and Zhen Dou and Jingde Zhu and Wei Xie and Zihe Rao and Xia Ding and Xuebiao Yao},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 39},
  pages={
          26726-36
        }
}
Chromosome movements in mitosis are orchestrated by dynamic interactions between spindle microtubules and the kinetochore, a multiprotein complex assembled onto centromeric DNA of the chromosome. Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells. Aurora B interacts with HsMis13 in vitro and in vivo. HsMis13 is a cognate substrate of Aurora B, and the phosphorylation sites were mapped to Ser-100 and Ser-109… CONTINUE READING

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Aurora B Interacts with HsMis13 26736 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • Dou, Jingde Zhu, +14 authors Zhaoyang Wang
  • July 17,
  • 2008
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