Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.

Abstract

Heat shock protein 27 (HSP27) (or HSPB1) exerts cytoprotection against many cellular insults, including cerebral ischemia. We previously identified apoptosis signal-regulating kinase 1 (ASK1) as a critical downstream target of HSP27 conferring the neuroprotective effects of HSP27 against neuronal ischemia. However, the function of HSP27 is highly influenced… (More)
DOI: 10.1523/JNEUROSCI.5169-11.2012

Topics

Cite this paper

@article{Stetler2012PhosphorylationOH, title={Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.}, author={Ruth Anne Stetler and Yanqin Gao and Lili Zhang and Zhongfang Weng and Feng Zhang and Xiaoming Hu and Suping Wang and Peter S Vosler and Guodong Cao and Dandan Sun and Steven H Graham and Jun Chen}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2012}, volume={32 8}, pages={2667-82} }