Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription

@article{Ammosova2006PhosphorylationOH,
  title={Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription},
  author={Tatyana Ammosova and Reem G Berro and Marina Jerebtsova and Angela Leckie Jackson and Sharroya M.n. Charles and Zachary A Klase and William M. Southerland and Victor R Gordeuk and Fatah Kashanchi and Sergei Nekhai},
  journal={Retrovirology},
  year={2006},
  volume={3},
  pages={78 - 78}
}
Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro. We also showed that CDK2 induces HIV-1 transcription in vitro and that inhibition of CDK2 expression by RNA interference inhibits HIV-1 transcription and viral replication in cultured cells. In the present study, we analyzed whether Tat is phosphorylated in… CONTINUE READING
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