Phosphorylation of Eukaryotic Translation Initiation Factor 2 B by Glycogen Synthase Kinase-3 Regulates-Adrenergic Cardiac Myocyte Hypertrophy

Abstract

Glycogen synthase kinase 3 (GSK-3 ) negatively regulates cardiac hypertrophy. A potential target mediating the antihypertrophic effect of GSK-3 is eukaryotic translation initiation factor 2B (eIF2B ). Overexpression of GSK-3 increased the cellular kinase activity toward GST-eIF2B in neonatal rat cardiac myocytes, whereas LiCl (10 mmol/L) or isoproterenol… (More)

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