Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation

@article{Sriram2011PhosphorylationOC,
  title={Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation},
  author={Ganapathy Sriram and Camila Reichman and Ahmet Tunceroglu and Neha Kaushal and Tamjeed Saleh and Kazuya Machida and Bjoern Mayer and Qingyuan Ge and Jingxia Li and Peter Hornbeck and Charalampos G. Kalodimos and Raymond B Birge},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={4645-4655}
}
Here, we report the identification and characterization of a novel tyrosine phosphorylation site in the carboxy-terminal Src Homology 3 (SH3) (SH3C) domain of the Crk adaptor protein. Y251 is located in the highly conserved RT loop structure of the SH3C, a region of Crk involved in the allosteric regulation of the Abl kinase. Exploiting kinase assays to show that Y251 is phosphorylated by Abl in vitro, we generated affinity-purified antisera against phosphorylated Y251 in Crk and showed that… CONTINUE READING
13 Extracted Citations
52 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 13 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…